Recombinant THAP1 protein (His tag)

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Recombinant Human THAP domain-containing protein 1 (THAP1) fragment (residues 1-77) is a high-purity protein designed for structural and biochemical studies. This fragment represents a stable and soluble unit of the transcription regulator THAP1, enabling research into its role in endothelial cell proliferation and cell-cycle progression without the complexities of the full-length protein.

THAP domain-containing protein 1 (THAP1), encoded by the THAP1 gene in Homo sapiens, functions as a DNA-binding transcription regulator critical for endothelial cell proliferation and G1/S cell-cycle progression. It specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and modulates expression of pRB-E2F cell-cycle target genes, such as RRM1, as part of a THAP1/THAP3-HCFC1-OGT complex. THAP1 also exhibits pro-apoptotic activity by enhancing serum-withdrawal and TNF-induced apoptosis. The protein localizes to the nucleus, particularly in the nucleoplasm and PML bodies, underscoring its involvement in nuclear regulatory processes. The provided fragment (residues 1-77) was selected computationally for its stability and solubility, facilitating targeted investigations into THAP1's functional mechanisms.