| QS-13 peptide | |
|---|---|
| Quantity/Unit | 1 Vial |
| Sequence | QKISRCQVCVKYS |
| Three letter code | H-Gln-Lys-Ile-Ser-Arg-Cys-Gln-Val-Cys-Val-Lys-Tyr-Ser-OH |
| Length | 13 |
| Peptide Purity (%) | 95.5 |
| Molecular Formula | C65H112N20O19S2 |
| Molecular Weight | 1541.83 |
| Source | Synthetic |
| Additional Information | Tetrastatin, a 230 amino acid sequence from collagen IV, was demonstrated to inhibit melanoma progression. The minimal active sequence (QKISRCQVCVKYS: QS-13) could reproduce the anti-tumor effects of whole Tetrastatin in vivo and in vitro on melanoma cell proliferation, migration and invasion. QS-13 binds to SK-MEL-28 melanoma cells through the αvβ3 integrin using blocking antibody and β3 integrin subunit siRNAs strategies. Relevant QS-13 conformations were extracted from molecular dynamics simulations and their interactions with αVβ3 integrin were analyzed by docking experiments to determine the binding areas and the QS-13 amino acids crucial for the binding. The in silico results were confirmed by in vitro experiments. Indeed, QS-13 binding to SK-MEL-28 was dependent on the presence of a disulfide-bound as shown by mass spectroscopy and the binding site on αVβ3 was located in close vicinity to the RGD binding site. QS-13 binding inhibits the FAK/PI3K/Akt pathway, a transduction pathway that is largely involved in tumor cell proliferation and migration. QS-13 peptide binds αvβ3 integrin in a conformation-dependent manner and is a potent antitumor agent that could target cancer cells through αVβ3. |
| Storage Guidelines | Ideally QS-13 peptide should be stored in a freezer at or below -9C. QS-13 peptide should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides |
| Terms | Please do not use the peptide for human consumption. NovoPro will immediately deny any order that we feel will be used outside of the scope of its intended purpose. |
| References |
Lambert E, Fuselier E, Ramont L, et al. Conformation-dependent binding of a Tetrastatin peptide to u03b1vu03b23 integrin decreases melanoma progression through FAK/PI3K/Akt pathway inhibition. Sci Rep. 2018;8(1):9837 |
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