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catalog peptide: QS-13 peptide

QS-13 peptide

Cat.#: 318732

Special Price 127.90 USD

Availability: 1-2 weeks

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Description
QS-13 peptide
Quantity/Unit 1 Vial
Sequence QKISRCQVCVKYS
Three letter code H-Gln-Lys-Ile-Ser-Arg-Cys-Gln-Val-Cys-Val-Lys-Tyr-Ser-OH
Length 13
Peptide Purity (%) 95.5
Molecular Formula C65H112N20O19S2
Molecular Weight 1541.83
Source Synthetic
Additional Information Tetrastatin, a 230 amino acid sequence from collagen IV, was demonstrated to inhibit melanoma progression. The minimal active sequence (QKISRCQVCVKYS: QS-13) could reproduce the anti-tumor effects of whole Tetrastatin in vivo and in vitro on melanoma cell proliferation, migration and invasion. QS-13 binds to SK-MEL-28 melanoma cells through the αvβ3 integrin using blocking antibody and β3 integrin subunit siRNAs strategies. Relevant QS-13 conformations were extracted from molecular dynamics simulations and their interactions with αVβ3 integrin were analyzed by docking experiments to determine the binding areas and the QS-13 amino acids crucial for the binding. The in silico results were confirmed by in vitro experiments. Indeed, QS-13 binding to SK-MEL-28 was dependent on the presence of a disulfide-bound as shown by mass spectroscopy and the binding site on αVβ3 was located in close vicinity to the RGD binding site. QS-13 binding inhibits the FAK/PI3K/Akt pathway, a transduction pathway that is largely involved in tumor cell proliferation and migration. QS-13 peptide binds αvβ3 integrin in a conformation-dependent manner and is a potent antitumor agent that could target cancer cells through αVβ3.
Storage Guidelines Ideally QS-13 peptide should be stored in a freezer at or below -9C. QS-13 peptide should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
Terms Please do not use the peptide for human consumption. NovoPro will immediately deny any order that we feel will be used outside of the scope of its intended purpose.
References

Lambert E, Fuselier E, Ramont L, et al. Conformation-dependent binding of a Tetrastatin peptide to u03b1vu03b23 integrin decreases melanoma progression through FAK/PI3K/Akt pathway inhibition. Sci Rep. 2018;8(1):9837

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