Recombinant TEAD4 protein (His tag)

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Recombinant Human TEAD4 Protein Fragment (aa 210-434) is a high-quality, stable, and soluble protein designed for structural and biochemical studies. This fragment of the Transcriptional enhancer factor TEF-3 (TEAD-4) is ideal for investigating its role in the Hippo signaling pathway, which regulates cell proliferation, migration, and organ size control.

The full-length TEAD4 protein, encoded by the TEAD4 gene in Homo sapiens, is a key transcription factor in the Hippo signaling pathway. This pathway is crucial for organ size regulation and tumor suppression by inhibiting proliferation and promoting apoptosis. TEAD4 mediates gene expression driven by YAP1 and WWTR1/TAZ, influencing processes such as epithelial-mesenchymal transition (EMT). It binds specifically to DNA motifs like Sph, GT-IIC, and M-CAT to activate transcription. TEAD4 is localized in the nucleus, underscoring its direct role in gene regulation. The provided fragment (aa 210-434) was selected for its stability and solubility, enabling detailed mechanistic studies without functional domains, based on computational predictions.