Recombinant TDGF3 protein (His tag)

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Recombinant Human CRIPTO3 Protein Fragment (residues 81-188) is a high-quality, stable, and soluble protein designed for structural and biochemical research. This fragment represents a key region of the CRIPTO3 protein, which is involved in critical developmental processes, including mesoderm specification and Nodal signaling pathway activation.

CRIPTO3, also known as Cripto-3 growth factor or Teratocarcinoma-derived growth factor 3, is a member of the EGF-CFC family and plays a significant role in early embryonic development. Based on available data, it contributes to the determination of epiblastic cells that give rise to the mesoderm and activates the Nodal-dependent signaling pathway, which is essential for cell differentiation and tissue patterning. The protein is localized to the cell membrane as a peripheral membrane protein, facilitating its interactions in signaling processes. The recombinant fragment (residues 81-188) was computationally selected to provide a stable and soluble unit, enabling detailed studies of CRIPTO3's functional properties without the complexities of the full-length protein.