Recombinant TDGF1 protein (His tag)

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Recombinant Human Protein Cripto Fragment (residues 80-150) is a high-purity, soluble protein designed for structural and biochemical studies. This fragment, derived from the Cripto-1 growth factor, represents a stable and well-folded region ideal for investigating its role in Nodal signaling and developmental processes.

Protein Cripto, encoded by the CRIPTO gene, is a GPI-anchored membrane protein critical for Nodal signaling during embryonic development. It functions as a coreceptor for Nodal, with cell-associated CRIPTO facilitating signaling in cis, while its shedding by TMEM8A enables soluble CRIPTO to act as a coreceptor in trans, modulating intercellular communication. This protein is implicated in determining epiblastic cells that give rise to mesoderm, highlighting its importance in early developmental events. Subcellularly, it localizes to the cell membrane via a GPI anchor and can be secreted following GPI cleavage, allowing for both membrane-bound and soluble signaling activities.

80-150