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Product Name
Recombinant TCF7 protein (His tag)
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Description
This recombinant protein is a fragment of human Transcription factor 7 (TCF-7), spanning residues 268-344. It is designed as a stable and soluble unit ideal for structural studies and biochemical assays, supporting research into T-cell differentiation and transcriptional regulation.
Transcription factor 7 (TCF-7), encoded by the TCF7 gene, is a transcriptional activator critical for T-cell lymphocyte differentiation and the survival of immature thymocytes. It binds to specific enhancer elements, such as in the CD3E gene promoter, and represses the T-cell receptor gamma gene in alpha-beta T-cell lineages. The protein is also involved in the development of natural killer receptor-positive lymphoid tissue inducer T-cells and can act as a feedback repressor for target genes of CTNNB1 and TCF7L2, with interactions modulated by TLE family proteins. TCF-7 is localized to the nucleus, underscoring its role in gene regulation.
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Protein name
Transcription factor 7
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Uniprot ID
P36402
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Gene Name
TCF7; TCF1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 268-344 aa (P36402) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 10.83 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 11 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"