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Product Name
Recombinant TBX19 protein (His tag)
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Description
Recombinant Human TBX19 (40-222) Fragment - A highly stable and soluble protein fragment of the T-box transcription factor TBX19, specifically designed for structural biology and biochemical studies. This 183-amino acid fragment maintains key structural integrity while offering enhanced experimental utility for researchers investigating transcriptional regulation mechanisms.
TBX19 is a crucial transcriptional regulator involved in developmental processes, with demonstrated ability to activate POMC gene expression while repressing both alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters. As a nuclear-localized protein, TBX19 functions within the nucleus to control gene expression patterns essential for proper cellular development and differentiation. The selected fragment (amino acids 40-222) represents a computationally optimized region that preserves structural stability and solubility, making it particularly valuable for researchers studying the molecular mechanisms of T-box transcription factors in developmental biology and endocrine regulation.
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Protein name
T-box transcription factor TBX19
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Uniprot ID
O60806
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Gene Name
TBX19; TPIT
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 40-222 aa (O60806) were fused with 6His tag.
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Sequence
40-222
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 22.50 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 22 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"