Recombinant TAZ protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Tafazzin (Taz) Fragment (1-262) is a high-purity, stable protein product designed for structural and biochemical research. This fragment encompasses the key functional region of Tafazzin, an acyltransferase critical for cardiolipin remodeling in mitochondrial membranes. It is ideal for studying mitochondrial lipid metabolism, enzyme kinetics, and protein-lipid interactions in vitro.

Tafazzin (TAFAZZIN gene) is a mitochondrial acyltransferase essential for remodeling cardiolipin (CL), a phospholipid vital for mitochondrial inner membrane structure and function. It catalyzes transacylation reactions, primarily between phosphatidylcholine and CL, to optimize acyl chain composition, thereby supporting respiratory chain complex assembly, mitochondrial membrane dynamics, and overall mitochondrial performance. Tafazzin is also implicated in processes like mitophagy initiation and spermatogenesis. The full-length protein localizes to both mitochondrial outer and inner membranes, with specific isoforms exhibiting distinct catalytic activities and subcellular distributions. This recombinant fragment (1-262) represents a soluble, stable unit selected for experimental studies, retaining functional relevance to Tafazzin's role in lipid metabolism.