Recombinant TAU protein (His tag)

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This recombinant protein product features a stable and soluble fragment (residues 570-693) of human Microtubule-associated protein tau (MAPT), designed for structural and biochemical studies. This 124-amino acid fragment is ideal for investigating tau's role in cytoskeletal dynamics and neuronal function without the complexities of the full-length protein.

Microtubule-associated protein tau (MAPT) is a crucial neuronal protein that promotes microtubule assembly and stability, playing a key role in establishing and maintaining neuronal polarity. It functions as a linker between axonal microtubules and neural plasma membrane components, with shorter isoforms contributing to cytoskeletal plasticity and longer isoforms aiding in stabilization. Tau is primarily localized to the cytoplasm, cytosol, cytoskeleton, and neuronal projections (axons and dendrites), and can also associate with the cell membrane as a peripheral protein. Notably, tau can be secreted via an unconventional pathway involving TMED10-mediated translocation. Dysregulation of tau is associated with neurodegenerative pathologies, including neurofibrillary tangles in Alzheimer's disease, underscoring its significance in neuroscience research.