TALPID3 Rabbit Polyclonal antibody. Positive WB detected in mouse embryo tissue. Observed molecular weight by Western-blot: 60 kDa
Human, Mouse; other species not tested.
KIAA0586 antibody; KIAA0586 isoform antibody; Talpid3 antibody
This antibody was obtained by immunization of TALPID3 recombinant protein (Accession Number: BC066647). Purification method: Antigen affinity purified.
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
mouse embryo tissue were subjected to SDS PAGE followed by western blot with Catalog No:115846(KIAA0586 Antibody) at dilution of 1:600
KIAA0586 also named as Talpid3 is a 1472 amino-acid protein, which belongs to Talpid3 family. Talpid3 is a gene essential for vertebrate development. Studies in chicken, mouse, zebrafish and human have shown that TALPID3 is a centrosomal protein, mutants null for TALPID3 fail to produce cilia, resulting in far reaching signalling defects such as polydactyly, dorsalised neural tube, craniofacial and vascular defects often due to abnormalities in Hedgehog signal transduction. Talpid3 is absolutely required for the function of both Gli repressor and activator in the intracellular Hedgehog pathway and ciliogenesis. TALPID3 may be identified as a subcellular maker of centrosome and needed to further studied.
- Stephen LA, Tawamie H, Davis GM. TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23). eLife. 4:. 2015.
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