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  • TALPID3 antibody

TALPID3 antibody

Cat.#: 115846

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Special Price 239.0 USD

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Product Information

  • Product Name
    TALPID3 antibody
  • Documents
  • Description
    TALPID3 Rabbit Polyclonal antibody. Positive WB detected in mouse embryo tissue. Observed molecular weight by Western-blot: 60 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    KIAA0586 antibody; KIAA0586 isoform antibody; Talpid3 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of TALPID3 recombinant protein (Accession Number: BC066647). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

  • Validations

    mouse embryo tissue were subjected to SDS PAGE followed by western blot with Catalog No:115846(KIAA0586 Antibody) at dilution of 1:600

    mouse embryo tissue were subjected to SDS PAGE followed by western blot with Catalog No:115846(KIAA0586 Antibody) at dilution of 1:600

  • Background
    KIAA0586 also named as Talpid3 is a 1472 amino-acid protein, which belongs to Talpid3 family. Talpid3 is a gene essential for vertebrate development. Studies in chicken, mouse, zebrafish and human have shown that TALPID3 is a centrosomal protein, mutants null for TALPID3 fail to produce cilia, resulting in far reaching signalling defects such as polydactyly, dorsalised neural tube, craniofacial and vascular defects often due to abnormalities in Hedgehog signal transduction. Talpid3 is absolutely required for the function of both Gli repressor and activator in the intracellular Hedgehog pathway and ciliogenesis. TALPID3 may be identified as a subcellular maker of centrosome and needed to further studied.
  • References
    • Stephen LA, Tawamie H, Davis GM. TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23). eLife. 4:. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"