Recombinant TAF10 protein (His tag)

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This recombinant protein product features a stable 104-amino acid fragment (residues 115-218) of the human Transcription initiation factor TFIID subunit 10 (TAF10). This fragment has been computationally optimized for structural stability and solubility, making it an ideal reagent for biochemical studies, structural analysis, and functional investigations of TFIID complex assembly and transcriptional regulation.

Transcription initiation factor TFIID subunit 10 (TAF10) is an essential component of the TFIID basal transcription factor complex, which plays a central role in initiating RNA polymerase II-dependent transcription. TFIID recognizes and binds promoter regions, facilitating assembly of the pre-initiation complex. Beyond its core function in TFIID, TAF10 also participates in multiple chromatin-modifying complexes including the PCAF histone acetylase complex, TFTC, and STAGA transcription coactivator-HAT complex, highlighting its importance in transcriptional regulation through both direct promoter recognition and epigenetic modifications. The protein localizes to the nucleus, consistent with its fundamental role in gene expression regulation. This fragment provides researchers with a defined structural unit for mechanistic studies of TAF10's molecular interactions and functions.