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Product Name
Recombinant TAB1 protein (His tag)
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Description
Recombinant Human TAB1 (TGF-beta-activated kinase 1 and MAP3K7-binding protein 1) fragment (amino acids 1-370) encompassing the full PPM-type phosphatase domain. This high-purity protein is an essential tool for investigating JNK and NF-kappa-B signaling pathways, cytokine production, and TAK1 complex regulation in cellular and biochemical assays.
TAB1 is a critical adapter protein that plays a central role in innate immunity and inflammation by activating both JNK and NF-kappa-B signaling pathways in response to Toll-like receptor (TLR) and cytokine stimulation. It functions by binding to MAP3K7/TAK1's catalytic domain, triggering TAK1 autophosphorylation and full activation, and similarly activates MAPK14 through association. TAB1 also facilitates recruitment of MAPK14 to the TAK1 complex for phosphorylation of TAB2/TAB3 regulatory subunits, while MAPK14-mediated phosphorylation of TAB1 provides feedback inhibition of TAK1 activation. The protein localizes primarily to the cytoplasm and cytosol, wi
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Protein name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
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Uniprot ID
Q15750
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Gene Name
TAB1; MAP3K7IP1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-370 aa (Q15750) were fused with C-terminal 6His tag.
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Sequence
1-370
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 41.65 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 43 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant TAB1 protein (His tag) SDS-PAGE
M: Marker; Lane 1: TAB1; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"