Recombinant TAB1 protein (His tag)

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Recombinant Human TAB1 (TGF-beta-activated kinase 1 and MAP3K7-binding protein 1) fragment (amino acids 1-370) encompassing the full PPM-type phosphatase domain. This high-purity protein is an essential tool for investigating JNK and NF-kappa-B signaling pathways, cytokine production, and TAK1 complex regulation in cellular and biochemical assays.

TAB1 is a critical adapter protein that plays a central role in innate immunity and inflammation by activating both JNK and NF-kappa-B signaling pathways in response to Toll-like receptor (TLR) and cytokine stimulation. It functions by binding to MAP3K7/TAK1's catalytic domain, triggering TAK1 autophosphorylation and full activation, and similarly activates MAPK14 through association. TAB1 also facilitates recruitment of MAPK14 to the TAK1 complex for phosphorylation of TAB2/TAB3 regulatory subunits, while MAPK14-mediated phosphorylation of TAB1 provides feedback inhibition of TAK1 activation. The protein localizes primarily to the cytoplasm and cytosol, with recruitment to the endoplasmic reticulum membrane following interaction with STING1, highlighting its importance in multiple cellular compartments and signaling contexts.