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Product Name
Recombinant SYT4 protein (His tag)
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Description
Recombinant Human Synaptotagmin-4 (SytIV) Fragment (residues 153-425) is a high-purity protein designed to encompass the C2 1 and C2 2 domains, enabling targeted investigation into their roles in neuronal vesicle dynamics and dendrite formation.
Synaptotagmin-4 (SytIV) is a member of the synaptotagmin family that, unlike some homologs, does not bind calcium. It plays a critical role in regulating the mobility of neuronal dense core vesicles (DCVs) through its interaction with KIF1A, a kinesin motor protein. Under increased neuronal activity, phosphorylation by MAPK8/JNK1 disrupts this interaction, facilitating the capture of DCVs at synapses. Additionally, SytIV contributes to dendrite formation in melanocytes. The protein localizes to the membranes of cytoplasmic vesicles, secretory vesicles, and neuronal dense core vesicles as a single-pass membrane protein, underscoring its importance in intracellular trafficking and neuronal function.
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Protein name
Synaptotagmin-4
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Uniprot ID
Q9H2B2
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Gene Name
SYT4; KIAA1342
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 153-425 aa (Q9H2B2) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 32.73 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 33 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"