Recombinant SYT1 protein (His tag)

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Recombinant Synaptotagmin-1 (Snt-1) Fragment (134-441) from Caenorhabditis elegans - a precisely engineered protein fragment containing both complete C2 domains (C2 1 and C2 2), providing researchers with an ideal tool for studying calcium-dependent membrane interactions and synaptic vesicle trafficking mechanisms.

Synaptotagmin-1 is a critical synaptic vesicle membrane protein that plays a regulatory role in membrane interactions during synaptic vesicle trafficking at the active zone. The protein binds acidic phospholipids with specificity requiring both an acidic head group and diacyl backbone, and has been implicated in necrotic cell death pathways. Native Synaptotagmin-1 localizes to cytoplasmic vesicles, secretory vesicles, and synaptic vesicle membranes, functioning as a single-pass membrane protein primarily found in synapses and vesicle-like structures. The full-length protein's involvement in both synaptic function and cell death mechanisms makes it an important target for neuroscience and cell biology research.