Recombinant SYNP2 protein (His tag)

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Recombinant Human Synaptopodin-2 Fragment (residues 1-87) is a high-quality protein product designed for structural and biochemical studies. This stable and soluble fragment retains key properties of the full-length protein, which is involved in actin cytoskeleton regulation, cell migration, and muscle Z-line stabilization. Ideal for researchers investigating cytoskeletal dynamics and protein-protein interactions.

Synaptopodin-2 (also known as Genethonin-2 or Myopodin), encoded by the SYNPO2 gene, is a multifunctional human protein with actin-binding and actin-bundling capabilities. It plays critical roles in cytoskeletal organization, cell migration regulation, and sarcomeric Z-line assembly in muscle tissues. The protein demonstrates isoform-specific functions in forming distinct actin network structures and participates in chaperone-assisted selective autophagy (CASA) for muscle maintenance under mechanical stress. Subcellular localization varies by differentiation state, with nuclear-cytoplasmic shuttling observed in myoblasts and predominant Z-line localization in differentiated myotubes. The protein also localizes to focal adhesions and cytoskeletal structures, positioning it as a key adapter protein linking mechanical signaling to cytoskeletal organization.