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Product Name
Recombinant STX5 protein (His tag)
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Description
Recombinant Syntaxin-5 (STX5) Fragment (aa 260-333): A high-purity, functional protein fragment designed for targeted research on endoplasmic reticulum to Golgi transport mechanisms. This 74-amino acid construct fully encompasses the t-SNARE coiled-coil homology domain, making it an ideal tool for studying vesicle tethering and fusion processes in cellular trafficking.
Syntaxin-5, encoded by the STX5 gene in humans, is a key mediator of endoplasmic reticulum to Golgi transport. It functions in vesicle tethering and fusion at the cis-Golgi membrane through interactions with p115/USO1 and GM130/GOLGA2, helping maintain the Golgi apparatus' stacked structure. The protein localizes to the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus membrane, predominantly in cis-most cisternae. Beyond its fundamental role in intracellular transport, Syntaxin-5 supports Golgi to endoplasmic reticulum retrograde transport and intra-Golgi transport through isoform-specific functions, and has been implicated in human cytomegalovirus infection by facilitating viral assembly compartment formation.
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Protein name
Syntaxin-5
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Uniprot ID
Q13190
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Gene Name
STX5; STX5A
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 260-333 aa (Q13190) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 10.12 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 11 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"