Recombinant STX17 protein (His tag)

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Recombinant Human Syntaxin-17 Fragment (2-110) is a high-purity, soluble protein designed for structural and biochemical studies. This fragment represents a stable region of Syntaxin-17, a key SNARE protein essential for autophagosome-lysosome fusion and membrane trafficking, enabling researchers to investigate its molecular mechanisms in autophagy and secretory pathways.

Syntaxin-17 (STX17), encoded by the STX17 gene in Homo sapiens (UniProt ID: P56962), is a SNARE protein critical for cellular membrane fusion processes. It functions in autophagy by mediating the fusion of autophagosome membranes with lysosomes, facilitating degradation and recycling of cellular components. Additionally, STX17 plays a role in the early secretory pathway, maintaining the architecture of the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and regulating transport between the endoplasmic reticulum, ERGIC, and Golgi. The protein localizes to multiple membranes, including the endoplasmic reticulum, autophagosomes, mitochondria, and autolysosomes, and adopts a hairpin-like insertion into membranes. Its involvement in membrane dynamics makes it a significant target for studying cellular homeostasis, autophagy, and trafficking disorders.