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Product Name
Recombinant STK33 protein (His tag)
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Description
Recombinant Human Serine/threonine-protein kinase 33 (STK33) Fragment (aa 100-404) - A high-purity protein kinase domain fragment ideal for studying kinase activity, spermatogenesis regulation, and cytoskeletal dynamics in research applications.
Serine/threonine-protein kinase 33 (STK33) is a crucial enzyme required for spermatid differentiation and male fertility. This kinase promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4. Additionally, STK33 phosphorylates vimentin, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton. The protein localizes to the cytoplasm, cytoskeleton, and perinuclear region, where it specifically colocalizes with the caudal end of the manchette - a transient structure that guides tail elongation in elongating spermatids. The provided fragment (amino acids 100-404) encompasses the complete protein kinase domain (116-381), making it an excellent tool for investigating the catalytic functions and substrate interactions of this important reproductive and cytoskeletal regulator.
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Protein name
Serine/threonine-protein kinase 33
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Uniprot ID
Q9BYT3
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Gene Name
STK33
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 100-404 aa (Q9BYT3) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 36.46 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 39 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"