SRY antibody

Cat.#: 115603

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Product Information

  • Product Name
    SRY antibody
  • Documents
  • Description
    SRY Rabbit Polyclonal antibody. Positive WB detected in human testis tissue. Positive IHC detected in human kidney tissue, human spleen tissue, human testis tissue. Observed molecular weight by Western-blot: 30kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    sex determining region Y antibody; SRY antibody; TDF antibody; TDY antibody; Testis determining factor antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of SRY recombinant protein (Accession Number: NM_003140). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    human testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:115603(SRY antibody) at dilution of 1:500

    human testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:115603(SRY antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:115603(SRY antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:115603(SRY antibody) at dilution of 1:100 (under 10x lens)

  • Background
    SRY (sex-determining region Y protein) is a tran-scriptional activator required for male sex determination in mammals. This protein, also referred to as testis-determining factor (TDF), is an HMG box protein that initiates the formation of testis from undifferentiated gonad. The DNA-binding activity of SRY is required for normal testis formation. This DNA-binding activity is thought to be regulated by PKA, which phosphorylates SRY in vivo. Mutations in SRY have been associated with 46,XY gonadal dysgenesis, in which the gonads fail to develop in XY phenotypic females.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"