Recombinant SRRM1 protein (His tag)

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Recombinant Human SRRM1 Protein Fragment (1-165) is a high-purity, functionally relevant fragment encompassing the PWI domain of Serine/arginine repetitive matrix protein 1 (SRm160). This product is engineered for researchers studying splicing regulation, mRNA processing, and nuclear matrix interactions, offering a targeted tool for domain-specific functional analyses.

The full-length SRRM1 protein is a critical component of pre- and post-splicing multiprotein mRNP complexes, primarily involved in constitutive and enhancer-dependent splicing activation within the minor spliceosome for U12-type introns. It functions by bridging sequence-specific splicing factors (e.g., SFRS4, SFRS5, TRA2B) with basal snRNP components (e.g., SNRP70, SNRPA1) to promote mRNA processing. Additionally, SRRM1 stimulates mRNA 3'-end cleavage independently of exon junction complexes and binds nucleic acids upstream of exon-exon junctions with low sequence specificity. It localizes to the nuclear matrix and speckles, underscoring its role in nuclear organization and RNA metabolism. The provided fragment (1-165) includes the PWI domain, enabling focused investigations into its contributions to these processes.

1-165