-
Product Name
Recombinant SPIN4 protein (His tag)
- Documents
-
Description
Recombinant Spindlin-4 (SPIN4) fragment (residues 39-249) from Homo sapiens, designed for robust experimental use. This 211-amino acid fragment retains key structural integrity, offering a soluble and stable tool for investigating histone recognition and WNT signaling modulation in cellular processes.
Spindlin-4, encoded by the SPIN4 gene in humans, functions as a histone reader that binds to acetylated and methylated histone marks such as H3K4me3 and H4K20me3. This interaction enables Spindlin-4 to interpret chromatin modifications and mediate downstream cellular effects, including the promotion of canonical WNT signaling and regulation of cell proliferation. The protein localizes to both the cytoplasm and nucleus, underscoring its versatile role in epigenetic regulation and signaling pathways.
-
Protein name
Spindlin-4
-
Uniprot ID
Q56A73
-
Gene Name
SPIN4
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 39-249 aa (Q56A73) were fused with C-terminal 6His tag.
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 25.85 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 28 kDa band.
-
Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
-
Validations
Recombinant SPIN4 protein (His tag) SDS-PAGE
M: Marker; Lane 1: SPIN4; Lane 2: BSA
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"