Recombinant SP100 protein (His tag)

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Recombinant Human Nuclear Autoantigen Sp-100 Fragment (aa 594-839) - A high-purity protein fragment specifically designed to encompass the SAND domain (aa 595-676) of the SP100 protein. This fragment serves as an essential research tool for investigating the domain-specific functions of this important nuclear protein involved in transcriptional regulation, apoptosis, and viral defense mechanisms.

The full-length Nuclear Autoantigen Sp-100 is a critical tumor suppressor and major constituent of PML bodies, subnuclear organelles involved in numerous physiological processes including cell growth, differentiation, and apoptosis. It functions as a transcriptional coactivator of ETS1 and ETS2, playing roles in angiogenesis by controlling endothelial cell motility and invasion. Through interaction with the MRN complex, SP100 participates in telomere length regulation and modulates TP53-mediated transcription. The protein also regulates FAS-mediated apoptosis via CASP8AP2 and plays significant roles in viral defense against human cytomegalovirus and Epstein-Barr virus through chromatin and transcriptional regulation mechanisms. SP100 exhibits dynamic subcellular localization, primarily in nuclear PML bodies and nuclear bodies, with cytoplasmic accumulation observed upon FAS activation, and its distribution varies by isoform and cell cycle phase.