Recombinant SP1 protein (His tag)

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Recombinant human Transcription factor Sp1 fragment (residues 625-709) is a highly stable and soluble protein unit, ideal for structural and biochemical studies. This 85-amino acid fragment enables researchers to investigate the molecular mechanisms of Sp1, a key regulator of gene expression involved in critical cellular processes.

Transcription factor Sp1 (UniProt ID: P08047) is a versatile human protein that activates or represses transcription in response to physiological and pathological stimuli. It binds GC-rich motifs and regulates numerous genes involved in cell growth, apoptosis, differentiation, immune responses, and DNA damage response. Sp1 is highly regulated by post-translational modifications including phosphorylation, sumoylation, and glycosylation, and plays roles in chromatin remodeling and maintaining telomerase activity in cancer cells. It localizes primarily to the nucleus, with its subcellular distribution modulated by glycosylation/phosphorylation states and hormonal signals such as insulin and glucagon.