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Product Name
Recombinant SOX10 protein (His tag)
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Description
Recombinant Human SOX-10 (66-179) is a high-quality protein fragment derived from the transcription factor SOX-10, essential for glial development and myelination. This 114-amino acid fragment has been computationally optimized for stability and solubility, making it an ideal tool for structural studies, biochemical assays, and functional investigations in neuroscience and cell biology research.
Transcription factor SOX-10 plays a central role in the development and function of glial cells, particularly in oligodendrocyte maturation and central nervous system myelination. It activates key myelin genes such as DUSP15, MYRF, and MBP, and synergistically regulates MITF expression alongside PAX3. SOX-10 localizes to multiple cellular compartments including the nucleus, cytoplasm, and mitochondrial outer membrane, reflecting its diverse functional interactions. The protein fragment (amino acids 66-179) represents a stable, soluble region selected for experimental applications while maintaining relevance to SOX-10's biological significance in neural development and myelination processes.
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Protein name
Transcription factor SOX-10
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Uniprot ID
P56693
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Gene Name
SOX10
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 66-179 aa (P56693) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 15.17 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"