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Product Name
Recombinant SOSB1 protein (His tag)
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Description
Recombinant Human SOSS complex subunit B1 (NABP2) fragment (amino acids 1-119) is a high-quality protein product designed for structural and biochemical studies. This stable and soluble fragment retains key functional characteristics, making it ideal for investigating DNA repair mechanisms and single-stranded DNA interactions in vitro.
SOSS complex subunit B1 (also known as NABP2, hSSB1) is a critical component of the SOSS multiprotein complex that functions downstream of the MRN complex in DNA damage response pathways. This protein acts as a sensor of single-stranded DNA, with particular affinity for polypyrimidine sequences, and plays essential roles in promoting DNA repair, G2/M checkpoint activation, and maintaining genomic stability. The full-length protein localizes to the nucleus and forms distinct nuclear foci following DNA damage, partially colocalizing with RAD51 after ionizing radiation treatment. It is required for efficient homologous recombination-dependent repair of double-strand breaks and ATM-dependent signaling pathways, making it a key player in cellular response to genomic stress.
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Protein name
SOSS complex subunit B1
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Uniprot ID
Q9BQ15
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Gene Name
NABP2; OBFC2B; SSB1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-119 aa (Q9BQ15) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 14.84 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"