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Product Name
Recombinant SODE protein (His tag)
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Description
Recombinant Human Extracellular Superoxide Dismutase [Cu-Zn] (EC-SOD) Fragment (residues 19-240) is a high-purity protein designed for structural and biochemical studies. This fragment encompasses the stable, soluble core domain of EC-SOD, enabling reliable investigation of its antioxidant function in converting superoxide radicals to hydrogen peroxide and oxygen.
Extracellular superoxide dismutase [Cu-Zn] (EC-SOD), encoded by the SOD3 gene in humans, plays a critical role in protecting the extracellular space from reactive oxygen intermediates by catalyzing the conversion of superoxide radicals into hydrogen peroxide and oxygen. The enzyme is primarily secreted into the extracellular space, with the majority anchored to heparan sulfate proteoglycans in tissue interstitium and a minor fraction circulating in the vasculature. This localization underscores its importance in mitigating oxidative stress in extracellular environments, contributing to cellular defense mechanisms.
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Protein name
Extracellular superoxide dismutase [Cu-Zn]
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Uniprot ID
P08294
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Gene Name
SOD3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 19-240 aa (P08294) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 25.79 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 26 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"