Recombinant SOCS3 protein (His tag)

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Introducing the recombinant Suppressor of cytokine signaling 3 (SOCS-3) fragment (amino acids 1-129), a highly stable and soluble protein unit ideal for structural studies and biochemical assays. This fragment, derived from human SOCS3, retains key functional relevance and is optimized for research applications exploring cytokine signaling regulation.

SOCS3 is a critical regulator of cytokine signaling pathways, functioning as part of a classical negative feedback system that modulates JAK/STAT signal transduction. It inhibits cytokine signaling by binding to receptors such as IL6ST/gp130, LIF, erythropoietin, and leptin receptors, and directly suppresses JAK2 kinase activity to regulate IL6 signaling. SOCS3 also plays roles in suppressing fetal liver erythropoiesis and modulating allergic responses mediated by T-helper type 2 cells. Additionally, it acts as a substrate recognition component in E3 ubiquitin-protein ligase complexes, facilitating ubiquitination and proteasomal degradation of target proteins, thereby contributing to cellular homeostasis and immune regulation.