SIRT3 antibody

Cat.#: 115244

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Product Information

  • Product Name
    SIRT3 antibody
  • Documents
  • Description
    SIRT3 Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue, human spleen tissue, mouse kidney tissue, mouse skeletal muscle tissue. Observed molecular weight by Western-blot: 28 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    hSIRT3 antibody; SIR2 like protein 3 antibody; SIR2L3 antibody; SIRT3 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of SIRT3 recombinant protein (Accession Number: NM_012239). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

  • Validations

    mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:115244(SIRT3 Antibody) at dilution of 1:300

    mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:115244(SIRT3 Antibody) at dilution of 1:300

  • Background
    Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) and SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. It is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2. SIRT3 is stress-responsive and its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death. full-length hSIRT3 (44 kDa) is an inert protein and that it is activated inside the mitochondria following deletion of 142 amino acids of the N-terminal segment. This processed form of SIRT3 is approximately 28 kDa and possesses deacetylase activity. The full SIRT3 is a 44 kDa protein and is processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"