SIGMAR1 Polyclonal Antibody

SIGMAR1 Polyclonal Antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Polyclonal antibody to SIGMAR1

WB, IHC

Human, Mouse, Rat

SIGMAR1 antibody; ALS16 antibody; DSMA2 antibody; OPRS1 antibody; SIG-1R antibody; SR-BP antibody; SR-BP1 antibody; SRBP antibody; hSigmaR1 antibody; sigma1R antibody; sigma non-opioid intracellular receptor 1 antibody

Rabbit IgG

Antigen: Recombinant protein of human SIGMAR1

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20℃. Avoid freeze / thaw cycles.

WB 1:500 - 1:2000
IHC 1:100 - 1:200

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).