SHLP2 peptide

SHLP2 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-MGVKFFTLSTRFFPSVQRAVPLWTNS-OH

H-Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser-OH

26

98.42%

C₁₄₂H₂₁₄N₃₆O₃₅S

3017.49

Synthetic

Powder

SHLP2 is a bioactive peptide derived from mitochondria that has been shown to modulate cell function and enhance cell viability. SHLP2 has been found to increase mitochondrial oxygen consumption rate (OCR) and cellular ATP levels, indicating that it enhances mitochondrial metabolism. SHLP2 has also been shown to activate the ERK and STAT3 signaling pathways, which are involved in cellular protection. In addition, SHLP2 has been found to have a protective effect against cytotoxicity in neurons and can prevent neuronal cell death caused by amyloid beta toxicity.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY). 2016 Apr;8(4):796-809. doi: 10.18632/aging.100943. PMID: 27070352; PMCID: PMC4925829.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.