Recombinant SFRP4 protein (His tag)

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Recombinant Human Secreted Frizzled-Related Protein 4 (sFRP-4) Fragment (aa 19-141) is a high-purity protein designed for studying Wnt signaling modulation. This fragment fully encompasses the functional FZ domain, making it an ideal tool for investigating domain-specific interactions in cellular growth, differentiation, and phosphate uptake regulation.

Secreted frizzled-related protein 4 (sFRP-4) functions as a key modulator of Wnt signaling pathways through direct interaction with Wnt proteins, playing crucial roles in regulating cell growth and differentiation. The full-length protein is involved in bone morphogenesis, adult uterine morphology maintenance, and apoptosis regulation during ovulation, potentially through FZ1/FZ4/WNT4 signaling pathways. Notably, sFRP-4 demonstrates phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. As a secreted protein, it primarily functions extracellularly, though cytoplasmic localization has been observed in ovarian tumor cells, highlighting its diverse cellular context-dependent roles.