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Recombinant SEPT8 protein (His tag)

Recombinant SEPT8 protein (His tag)

Cat.#: 545591

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Special Price 294.7 USD

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Product Information

  • Product Name
    Recombinant SEPT8 protein (His tag)
  • Documents
  • Description

    Recombinant Human Septin-8 Fragment (aa 2-408) is a high-quality protein preparation designed for studying the specific functions of the septin-type GTPase domain. This fragment encompasses the complete functional domain (aa 41-307) of Septin-8, a filament-forming cytoskeletal GTPase involved in critical cellular processes including platelet secretion and synaptic vesicle dynamics.

    Septin-8 is a filament-forming cytoskeletal GTPase that plays important roles in platelet secretion and appears to participate in SNARE complex formation in synaptic vesicles. The protein localizes to the cytoplasm, cytoskeleton, synapses, axons, and synaptic vesicle membranes. In platelets, it's found in areas surrounding alpha-granules, while in neurons it localizes to axons in immature cells and synapses in mature neurons. Additionally, isoform 4 of Septin-8 stabilizes BACE1 protein levels and promotes its sorting to recycling or endosomal compartments, modulating beta-amyloidogenic processing of APP, suggesting potential relevance to Alzheimer's disease pathways.

  • Protein name
    Septin-8
  • Uniprot ID
    Q92599
  • Gene Name
    SEPTIN8; KIAA0202; SEPT8
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 2-408 aa (Q92599) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 48.94 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 56 kDa band.
  • Purity
    >90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"