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Product Name
Recombinant SENP2 protein (His tag)
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Description
This recombinant protein is a fragment of Sentrin-specific protease 2 (SENP2), encompassing residues 367-589 from Homo sapiens. It represents a stable, soluble unit ideal for investigating SUMO pathway dynamics, including SUMO maturation and deconjugation, in structural and biochemical studies.
Sentrin-specific protease 2 (SENP2) is a crucial enzyme in the SUMO pathway, performing two essential functions: it processes SUMO propeptides (SUMO1, SUMO2, and SUMO3) into their mature forms and deconjugates SUMO from target proteins, regulating processes such as Wnt signaling, adipogenesis via CEBPB stabilization, and the cGAS-STING pathway during viral infection. Located primarily in the nucleus, particularly at the nuclear pore complex, and shuttling between the nucleus and cytoplasm, SENP2 plays a dynamic role in cellular regulation and protein stability.
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Protein name
Sentrin-specific protease 2
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Uniprot ID
Q9HC62
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Gene Name
SENP2; KIAA1331
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 367-589 aa (Q9HC62) were fused with N-terminal 6His tag.
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Sequence
367-589
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 28.06 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 28 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant SENP2 protein (His tag) SDS-PAGE
M: Marker; Lane 1: SENP2; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"