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Product Name
Recombinant SEL7 protein (His tag)
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Description
Recombinant fragment of Putative transcription factor sel-7 (Suppressor/enhancer of lin-12 protein 7), encompassing residues 150-258. This 109-amino acid fragment represents a stable, soluble unit ideal for structural studies and biochemical characterization of this key regulator of the lin-12/Notch signaling pathway in C. elegans.
The full-length Putative transcription factor sel-7 functions as a positive regulator of the lin-12/Notch signaling pathway and plays critical roles in cell fate decisions requiring cell-cell interactions, such as the anchor cell/ventral uterine precursor cell fate determination. As a heterochronic protein, sel-7 controls stage-specific cell fates, including larval L3 stage-specific seam cell fates, and regulates the temporal expression pattern of hunchback-like protein hbl-1 during larval development transitions. The protein localizes to the nucleus where it binds specific DNA sequences in regulatory elements, functioning as a transcription factor in developmental timing and cell fate specification processes.
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Protein name
Putative transcription factor sel-7
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Uniprot ID
G5EGS7
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Gene Name
sel-7
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 150-258 aa (G5EGS7) were fused with 6His tag.
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Sequence
150-258
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Protein Species
Caenorhabditis elegans
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Molecular weight
Predictes a molecular mass of 14.20 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 14 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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