Recombinant SEA2 protein (His tag)

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Recombinant Signal element on autosome protein 2 (sea-2) fragment (residues 1825-1968) from Caenorhabditis elegans, a 144-amino acid segment engineered for stability and solubility. This fragment enables structural and biochemical investigations of sea-2's roles in RNA binding, developmental timing regulation, and sex determination pathways.

The full-length sea-2 protein is an RNA-binding protein critical for developmental timing regulation during the L2 to L3 larval stage transition in C. elegans. It post-transcriptionally represses lin-28 expression via 3'UTR binding, controls seam cell division timing, and regulates adult alae differentiation. Additionally, sea-2 activates transcription of the sex-determining factor xol-1, influencing sex determination and X chromosome dosage compensation to promote male development. It also contributes to fox-1-sex-1-mediated sexual fate determination and intestinal regulation of adult lifespan. Sea-2 localizes to both nucleus and cytoplasm, with dynamic nuclear accumulation patterns during embryonic and larval stages, and exhibits DNA-binding capability through its first zinc finger domain in vitro.