SDHC antibody

Cat.#: 115033

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Product Information

  • Product Name
    SDHC antibody
  • Documents
  • Description
    SDHC Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue. Positive WB detected in human liver tissue, HepG2 cells, MCF7 cells, mouse lung tissue. Observed molecular weight by Western-blot: 15kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    CYB560 antibody; CYBL antibody; PGL3 antibody; QPs 1 antibody; QPS1 antibody; SDH3 antibody; SDHC antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of SDHC recombinant protein (Accession Number: NM_003001). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:115033(SDHC antibody) at dilution of 1:400

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:115033(SDHC antibody) at dilution of 1:400

    Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115033(SDHC antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115033(SDHC antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115033(SDHC antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115033(SDHC antibody) at dilution of 1:100 (under 40x lens)

  • Background
    SDHC(Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is also named as CYB560, SDH3 and belongs to the cytochrome b560 family. It is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHC are the cause of paragangliomas type 3 (PGL3) and paraganglioma and gastric stromal sarcoma (PGGSS). It has a transit peptide of 29 amino acid and has 5 isoforms produced by alternative splicing.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"