Recombinant SCO1 protein (His tag)

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Recombinant Human Protein SCO1 homolog, mitochondrial (SCO1) fragment (residues 112-301) is a high-purity, stable protein designed for structural and biochemical research. This 190-amino acid fragment represents a soluble and functionally relevant region, ideal for studying copper metallochaperone activity and cytochrome c oxidase maturation.

Protein SCO1 homolog, mitochondrial, encoded by the SCO1 gene in Homo sapiens, is a copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). It stabilizes MT-CO2/COX2 during its maturation and facilitates copper transport to the Cu(A) site of this subunit. Additionally, SCO1 plays a role in regulating copper homeostasis by influencing the abundance and membrane localization of the copper transporter CTR1. The protein is localized to the mitochondrial inner membrane, where it functions as a single-pass membrane protein. This recombinant fragment (112-301) provides a stable, soluble unit for investigating SCO1's molecular mechanisms without the complexities of full-length membrane association.