Recombinant SBDS protein (His tag)

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Recombinant Ribosome maturation protein SBDS (Shwachman-Bodian-Diamond syndrome protein) fragment (residues 2-179) from Homo sapiens. This stable and soluble fragment is ideal for investigating ribosome assembly, biogenesis, and translational activation in structural and biochemical studies.

The full-length SBDS protein is essential for ribosome maturation and biogenesis. It collaborates with EFL1 to facilitate the GTP-dependent release of EIF6 from cytoplasmic 60S pre-ribosomes, enabling 80S ribosome assembly and activating ribosomes for translation. This process also recycles EIF6 to the nucleus, where it supports 60S rRNA processing and nuclear export. SBDS contributes to normal protein synthesis levels and may be involved in cellular stress resistance, DNA damage response, and cell proliferation. It is primarily localized in the cytoplasm, with lower levels in the nucleus and nucleolus, and dynamically redistributes during the cell cycle—detected in the nucleolus during G1 and G2 phases, diffusely in the nucleus during S phase, and at the mitotic spindle and microtubule organizing center during interphase.