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SARA antibody

Cat.#: 115069

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Product Information

  • Product Name
    SARA antibody
  • Documents
  • Description
    SARA Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue. Positive WB detected in mouse brain tissue, HeLa cells, human brain tissue, MCF7 cells. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 156 kDa
  • Tested applications
    ELISA, WB, IHC, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    hSARA antibody; Madh interacting protein antibody; MADHIP antibody; Novel serine protease antibody; NSP antibody; Receptor activation anchor antibody; SARA antibody; SMADIP antibody; ZFYVE9 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of SARA recombinant protein (Accession Number: XM_011542437). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:115069(ZFYVE9 antibody) at dilution of 1:1000

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:115069(ZFYVE9 antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:115069(ZFYVE9 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:115069(ZFYVE9 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:115069(ZFYVE9 antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:115069(ZFYVE9 antibody) at dilution of 1:50 (under 40x lens)

    IP Result of anti-ZFYVE9 (IP:Catalog No:115069, 5ug; Detection:Catalog No:115069 1:1000) with mouse brain tissue lysate 5000ug.

    IP Result of anti-ZFYVE9 (IP:Catalog No:115069, 5ug; Detection:Catalog No:115069 1:1000) with mouse brain tissue lysate 5000ug.

  • Background
    ZFYVE9, also known as SARA (Smad anchor for receptor activation), is a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SARA functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. SARA plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. SARA is possibly associated with TGF-beta receptor internalization.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"