Recombinant SAN protein (His tag)

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Recombinant Drosophila melanogaster Probable N-acetyltransferase san (EC 2.3.1.258), encompassing amino acids 1-184, provides researchers with a functional fragment containing the complete N-acetyltransferase domain. This high-quality protein enables detailed investigation of N-terminal acetylation mechanisms and sister chromatid cohesion processes in experimental systems.

The full-length Probable N-acetyltransferase san (gene: san) from Drosophila melanogaster is a dual-function enzyme with both N-alpha-acetyltransferase and N-epsilon-acetyltransferase activities. It acetylates the N-terminus of proteins retaining their initiating methionine and mediates acetylation of specific lysine side chains, including autoacetylation. This protein plays a critical role in establishing sister chromatid cohesion by coupling cohesion processes with DNA replication, ensuring proper sister chromatid pairing. It facilitates the interaction between Scc1/vtd and SMC3, likely through N-terminal acetylation of Scc1/vtd. During interphase, the protein localizes to the cytoplasm, transitioning to a punctate pattern throughout the entire cell during mitosis entry, and becomes uniformly distributed from metaphase through telophase. The protein also supports optimal replication of Ehrlichia chaffeensis in immune tissues, hemocytes, and fat body.