-
Product Name
Recombinant SAMN1 protein (His tag)
- Documents
-
Description
Introducing the recombinant SAMSN-1 (159-304) fragment, a high-purity protein derived from human SAMSN1. This product encompasses the SH3 domain, offering researchers a precise tool to investigate domain-specific functions such as protein-protein interactions, signaling regulation, and cytoskeletal dynamics in B-cell activation and cellular processes.
SAMSN-1, or SAM domain-containing protein SAMSN-1, is a hematopoietic adaptor protein that acts as a negative regulator of B-cell activation and modulates cell proliferation in vitro. It promotes RAC1-dependent membrane ruffle formation, reorganizes the actin cytoskeleton, and influences cell spreading and polarization. Additionally, SAMSN-1 stimulates HDAC1 activity and regulates LYN kinase activity by affecting its tyrosine phosphorylation. The protein shuttles between the nucleus and cytoplasm, localizing to actin-rich membrane ruffles and the cytoskeleton, underscoring its role in cellular signaling and structural organization. The provided fragment (residues 159-304) includes the SH3 domain, enabling focused studies on its interaction capabilities and functional contributions.
-
Protein name
SAM domain-containing protein SAMSN-1
-
Uniprot ID
Q9NSI8
-
Gene Name
SAMSN1; HACS1
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 159-304 aa (Q9NSI8) were fused with 6His tag.
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 18.46 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 20 kDa band.
-
Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"