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Product Name
Recombinant SAHH protein (His tag)
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Description
Recombinant Human Adenosylhomocysteinase (AdoHcyase) Fragment (residues 2-432) is a high-purity, soluble protein designed for structural and biochemical studies. This fragment retains key functional domains, offering a stable and active unit ideal for investigating S-adenosyl-L-homocysteine hydrolysis and copper ion binding.
Adenosylhomocysteinase (AdoHcyase), encoded by the AHCY gene in humans, catalyzes the hydrolysis of S-adenosyl-L-homocysteine to adenosine and homocysteine, a critical reaction in cellular methylation processes. The enzyme also binds copper ions, suggesting potential roles in metal homeostasis. It localizes to the cytoplasm, melanosome, nucleus, and endoplasmic reticulum, indicating broad involvement in diverse cellular compartments. The recombinant fragment (residues 2-432) encompasses the full-length functional domain, providing a reliable tool for exploring its enzymatic activity and interactions in research applications.
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Protein name
Adenosylhomocysteinase
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Uniprot ID
P23526
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Gene Name
AHCY; SAHH
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 2-432 aa (P23526) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 49.24 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 50 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"