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Product Name
Recombinant S6A12 protein (His tag)
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Description
Recombinant Human Sodium- and Chloride-Dependent Betaine Transporter (BGT-1) Fragment (aa 138-210) – A high-quality, soluble protein fragment derived from the SLC6A12 gene, ideal for structural studies, biochemical assays, and functional investigations of this key neurotransmitter and osmolyte transporter.
The full-length Sodium- and Chloride-Dependent Betaine Transporter (BGT-1), encoded by the SLC6A12 gene, mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent manner. It plays a critical role in regulating GABAergic transmission in the brain through GABA reuptake into presynaptic terminals and is involved in osmotic regulation in renal and hepatic tissues. The protein is localized to the basolateral cell membrane in the kidney and the cell membrane in hepatocytes, functioning as a multi-pass membrane protein. This recombinant fragment (aa 138-210) represents a stable, soluble unit selected for structural and biochemical applications, enabling focused studies on BGT-1's transport mechanisms without the complexities of the full-length membrane protein.
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Protein name
Sodium- and chloride-dependent betaine transporter
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Uniprot ID
P48065
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Gene Name
SLC6A12; BGT1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 138-210 aa (P48065) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 10.04 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 10 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"