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Product Name
S.cerevisiae PAM18/TIM14/YLR008C recombinant protein
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Description
Mitochondrial import inner membrane translocase subunit TIM14 (TIM14) is an essential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, TIM14 is required to stimulate activity of mtHSP70 (SSC1). TIM14 belongs to the DnaJ family, which has been involved in Hsp40/Hsp70 chaperone systems. As a mitochondrial chaperone, TIM14 functions as part of the TIM23 complex import motor to facilitate the import of nuclear-encoded proteins into the mitochondria. TIM14 also complexes with prohibitin complexes to regulate mitochondrial morphogenesis, and has been implicated in dilated cardiomyopathy with ataxia.
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Protein name
Pam18p(PAM18)
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Protein short names
TIM14; YLR008C
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Uniprot ID
Q07914
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the S.cerevisiae PAM18/TIM14/YLR008C Phe99-Lys168 is expressed.
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Protein Species
S.cerevisiae
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Purity
>95% as determined by SDS-PAGE.
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Validations
S.cerevisiae PAM18/TIM14/YLR008C recombinant protein
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