Recombinant RUXE protein (His tag)

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Recombinant Human Small nuclear ribonucleoprotein E (snRNP-E) fragment (residues 1-92) is a high-purity protein designed for studying pre-mRNA splicing mechanisms. This fragment fully encompasses the essential Sm domain, making it an ideal tool for investigating spliceosome assembly and function in molecular biology research.

Small nuclear ribonucleoprotein E (snRNP-E), encoded by the SNRPE gene, serves as a core component of spliceosomal U1, U2, U4, and U5 small nuclear ribonucleoproteins (snRNPs), which are fundamental building blocks of the spliceosome. It participates in both the pre-catalytic B complex and activated C complex stages of spliceosome assembly and is also involved in the minor spliceosome pathway for U12-type intron splicing. Additionally, as part of the U7 snRNP complex, it contributes to histone 3'-end processing. The protein localizes primarily to the nucleus, where it functions in splicing, with SMN-mediated assembly into core snRNPs occurring in the cytosol before nuclear transport. This makes it crucial for understanding RNA processing and gene regulation pathways.