Recombinant RORB protein (His tag)

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Recombinant Human Nuclear receptor ROR-beta (RORB) Fragment (aa 219-470) is a high-purity protein designed for studying the ligand-binding domain (LBD) of this key nuclear receptor. This fragment enables targeted research into ROR-beta's roles in photoreceptor development, circadian rhythm regulation, and transcriptional control, providing a precise tool for domain-specific functional assays.

Nuclear receptor ROR-beta (RZR-beta) is a DNA-binding monomeric receptor that recognizes ROR response elements (RORE) and exhibits intrinsic transcriptional activity. It plays critical roles in postnatal development of rod and cone photoreceptor cells by modulating differentiation through the NRL pathway and regulating OPN1SW expression in cones. The protein is also involved in maintaining circadian rhythm stability and contributes to neuronal patterning during development, including neocortical cytoarchitectural organization and thalamocortical innervation. ROR-beta functions as a nuclear protein localized to the nucleoplasm and can be modulated by natural ligands like all-trans retinoic acid, which act as inverse agonists. Isoform 1 specifically supports hindlimb motor control and retinal amacrine/horizontal cell differentiation, working synergistically with FOXN4 to regulate PTF1A expression.