RK-10, a specific PD-L1 binding peptide
Three letter code
Peptide Purity (HPLC)
RK-10, a specific PD-L1 binding peptide, could be used for detecting PD-L1 expressing tumors with immunohistochemistry or flow cytometry. Flow cytometry was performed on cell lines and patient tissues using a fluorescent peptide (RK-10-Cy5). Immunohistochemistry using a biotin-modified peptide (RK-10-Biotin) was tested against the FDA-approved SP263 clone on biopsied patient tissues. RK-10 shows staining in the tumor regions of FFPE tissues where the SP263 kit does not. RK-10-Cy5 peptide also demonstrates PD-L1 detection in NSCLC, breast, squamous cell carcinoma, and melanoma.
Ideally RK-10, a specific PD-L1 binding peptide should be stored in a freezer at or below -9C. RK-10, a specific PD-L1 binding peptide should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
- Caldwell, C., Johnson, C. E., Balaji, V. N., Balaji, G. A., Hammer, R. D., & Kannan, R. (2017). Identification and Validation of a PD-L1 Binding Peptide for Determination of PDL1 Expression in Tumors. Scientific Reports, 7(1).
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