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catalog peptide: RK-10, a specific PD-L1 binding peptide

RK-10, a specific PD-L1 binding peptide

Cat.#: 318728

Special Price 222.20 USD

Availability: Discontinued

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Description
RK-10, a specific PD-L1 binding peptide
Quantity/Unit 1 Vial
Sequence GSGSGSTYLCGAISLAPKAQIKESL
Three letter code H-Gly-Ser-Gly-Ser-Gly-Ser-Thr-Tyr-Leu-Cys-Gly-Ala-Ile-Ser-Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-Ser-Leu-NH2
Length 25
Peptide Purity (%) 95.2
Molecular Formula C105H177N29O35S1
Molecular Weight 2437.78
Source Synthetic
Additional Information RK-10, a specific PD-L1 binding peptide, could be used for detecting PD-L1 expressing tumors with immunohistochemistry or flow cytometry. Flow cytometry was performed on cell lines and patient tissues using a fluorescent peptide (RK-10-Cy5). Immunohistochemistry using a biotin-modified peptide (RK-10-Biotin) was tested against the FDA-approved SP263 clone on biopsied patient tissues. RK-10 shows staining in the tumor regions of FFPE tissues where the SP263 kit does not. RK-10-Cy5 peptide also demonstrates PD-L1 detection in NSCLC, breast, squamous cell carcinoma, and melanoma.
Storage Guidelines Ideally RK-10, a specific PD-L1 binding peptide should be stored in a freezer at or below -9C. RK-10, a specific PD-L1 binding peptide should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
Terms Please do not use the peptide for human consumption. NovoPro will immediately deny any order that we feel will be used outside of the scope of its intended purpose.
References

Caldwell, C., Johnson, C. E., Balaji, V. N., Balaji, G. A., Hammer, R. D., & Kannan, R. (2017). Identification and Validation of a PD-L1 Binding Peptide for Determination of PDL1 Expression in Tumors. Scientific Reports, 7(1).

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"