Recombinant RIPR2 protein (His tag)

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Recombinant Human RIPOR2 (Rho family-interacting cell polarization regulator 2) Fragment (aa 734-1068) is a high-purity, stable protein fragment designed for structural and biochemical studies. This 335-amino acid segment retains key solubility properties, enabling research into RHOA inhibition, cell polarization mechanisms, and roles in immune response and sensory cell function.

RIPOR2 is a crucial regulator of cell polarization and differentiation, primarily acting as an inhibitor of the small GTPase RHOA. It modulates diverse biological processes including T-lymphocyte adhesion and migration, neutrophil polarization and chemotaxis, and myoblast differentiation. The protein is essential for normal development and maintenance of hair cell stereocilia in the inner ear, with mutations linked to hearing impairment. Localized primarily in the cytoplasm, RIPOR2 also associates with cytoskeletal structures, filopodia, and stereocilia bases, where it participates in mechanosensory functions. The selected fragment (734-1068) represents a computationally optimized stable region suitable for investigating these fundamental cellular mechanisms.