Cart 2
Recombinant RIOK3 protein (His tag)

Recombinant RIOK3 protein (His tag)

Cat.#: 546423

Size:

Special Price 294.7 USD

Availability: 3-4 weeks
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Recombinant RIOK3 protein (His tag)
  • Documents
  • Description

    Recombinant Human Serine/threonine-protein kinase RIO3 (RIOK3) Fragment (aa 162-519) is a high-purity protein designed for studying kinase activity and domain-specific functions. This fragment fully encompasses the protein kinase domain, making it an ideal tool for investigating RIOK3's roles in immune signaling, ribosome biogenesis, and viral response pathways.

    Serine/threonine-protein kinase RIO3 (RIOK3) is a multifunctional enzyme involved in regulating type I interferon-dependent immune responses, playing a critical role in innate immunity against DNA and RNA viruses. It acts as an adapter protein facilitating TBK1 recruitment to IRF3 and phosphorylates IFIH1 to attenuate antiviral signaling. Additionally, RIOK3 participates in 40S ribosomal subunit biogenesis by processing 21S pre-rRNA to mature 18S rRNA and can inhibit CASP10-mediated NF-kappaB signaling activation. The protein is localized to the cytoplasm, where it executes these diverse cellular functions.

  • Protein name
    Serine/threonine-protein kinase RIO3
  • Uniprot ID
    O14730
  • Gene Name
    RIOK3; SUDD
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 162-519 aa (O14730) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 42.82 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 46 kDa band.
  • Purity
    >90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"