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Product Name
Rhesus CLEC5A / MDL1 / MDL-1 (Fc Tag) recombinant protein
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Description
CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
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Protein name
Uncharacterized protein
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Protein short names
MYELOID DAP12-ASSOCIATING LECTIN 1; LY100; TYPE II TRANSMEMBRANE PROTEIN MDL-1; CLEC5A; MEMBER A; CARBOHYDRATE-RECOGNITION DOMAIN) LECTIN; MEMBER A; CLECSF5; C-TYPE LECTIN SUPERFAMILY MEMBER 5; CARBOHYDRATE-RECOGNITION DOMAIN) LECTIN; C-TYPE LECTIN DOMAIN FAMILY 5 MEMBER A; C-TYPE (CALCIUM DEPENDENT; MDL1; SUPERFAMILY MEMBER 5; MDL-1; C-TYPE LECTIN DOMAIN FAMILY 5
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Uniprot ID
F7GAV1
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Gene Name
CLEC5A; EGK_14219
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rhesus CLEC5A (XP_001085243.1) (Pro28-Arg188) was expressed with the Fc region of mouse IgG1 at the N-terminus.
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Protein Species
Rhesus
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Molecular weight
The recombinant rhesus CLEC5A comprises 397 amino acids and has a calculated molecular mass of 45.3 KDa.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Cynomolgus CLEC5A / MDL1 / MDL-1 Protein (Fc Tag) SDS-PAGE
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"